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Why Early-Stage Founders Don’t Make Great Growth-Stage CEOs: A Neuroentrepreneurship Perspective

Neuroscience suggests that the distinctly different phases of a business’ growth – exploration (early-stage) and exploitation (scaling up, post product-market fit) – requires a profoundly different way founders must think and interact with the world.

The early-stage founder tends to thrive in the high-risk, high-reward environment – driven by novelty and the pursuit of innovative solutions – and supported by a brain that’s highly adaptable, creative, and resilient.

The growth-stage CEO tends to excel in a more structured environment – focusing on scaling and optimizing the business – which requires a brain adept at habit formation, stress management, and maintaining social cohesion.

Understanding these differences from a neuroscience perspective can help founders evolve with each phase of their venture’s maturation or allow scaling companies to find new leadership with the necessary mindset and skills for its new phase of growth.

Here are a few insights into the cognitive differences between the explorer and the executor.

Early-Stage Founder: The Explorer

High Neuroplasticity and Learning Orientation

In the early stages, entrepreneurs need to be highly adaptable, learning quickly from successes and failures. Neuroplasticity, the brain’s ability to reorganize itself by forming new neural connections, is crucial during this phase, particularly in the prefrontal cortex and associated neural networks. This flexibility allows for the rapid learning and adaptation essential in the uncertain environment of a startup.

Dopamine-Driven Risk-Taking and Novelty Seeking

The exploration phase is characterized by novelty and uncertainty. Dopamine pathways – projecting from the ventral tegmental area to the nucleus accumbens and prefrontal cortex – are hyperactive in early-stage founders, which drives risk-taking, novelty seeking, and the pursuit of innovative solutions.

Prefrontal Cortex Engagement

The prefrontal cortex is involved in planning complex cognitive behavior, personality expression, decision-making, and moderating social behavior. In the exploration phase, entrepreneurs rely heavily on their executive functions for creative problem-solving and adapting to new challenges.

Adaptive Stress Response

Early-stage founders often exhibit a more adaptive stress response, allowing them to remain resilient and motivated in the face of high uncertainty and frequent setbacks. This resilience can be supported by a balanced activation of the amygdala and effective stress management strategies.

Growth-Stage CEO: The Executor

Habit Formation and Operational Efficiency

Once a product-market fit is found, the focus shifts to scaling and optimizing the business. This phase is about optimizing for execution and efficiency, when growth-stage CEOs benefit from the basal ganglia’s capacity for habit formation, which allows for the standardization of processes and the development of routines.

Stress Management and Emotional Regulation

The growth phase involves managing larger teams, greater financial stakes, and more complex operations, which can increase stress levels. Effective growth-stage CEOs have well-developed emotional regulation capabilities, mediated by the amygdala and prefrontal cortex, allowing them to maintain composure and clear decision-making under pressure.

Serotonin and Leadership

Growth-stage CEOs must exhibit leadership styles that foster trust, loyalty, and social cohesion, which is supported by serotonin’s role in mood regulation and social behavior. This is crucial for maintaining a positive company culture and motivating a growing team.

Cognitive Flexibility and Efficiency

While cognitive flexibility remains important, growth-stage CEOs tend to balance this with a focus on efficiency and execution. This requires a more structured approach to problem-solving and decision-making, reflecting a shift towards more left-brain (analytical and logical) thinking.

Tactics for Early-Stage Founders to become Growth-Stage CEOs

For early-stage founders that want to continue leading their ventures through the growth phase, preparing for the transition requires the intentional development of specific skills and mental practices.

Here are five actionable insights to help founders effectively prepare for their evolution into growth-stage leadership:

Cultivate Habitual Processes

Larger companies rely on structure and discipline. Start integrating routine behaviors and processes into your daily operations to lay the groundwork for scaling operations efficiently later on. Begin by standardizing simple, repeatable tasks to build a foundation for operational efficiency.

Develop Emotional Regulation Strategies

Leading large teams can be stressful. Strengthen your emotion regulation with mindfulness practices, stress management techniques, and emotional intelligence training. This will enhance your ability to remain calm and make clear decisions under the increased pressures of growth-stage leadership.

Foster Social Cohesion

Leading large teams is as much about people and culture as it is about strategy and decision-making. Start early by actively building strong, trust-based relationships within your team. This involves nurturing your soft leadership skills, characterized by empathy, active listening, and open communication, to name a few.

Balance Cognitive Flexibility with Efficiency

While you need to maintain the cognitive flexibility that fueled your innovation in the first place, you should begin to focus more attention on efficiency and execution as you approach product-market fit. This may involve setting clearer goals, prioritizing tasks, and adopting more analytical approaches to problem-solving, reflecting a shift towards a more structured, left-brain mode of thinking. I recommend implementing OKRs.

Engage in Continuous Learning

Start learning new skills like operations, management, and leadership before you need them. Read books, take courses, or work with a coach or mentor. This will aid in creating a smoother transition to the growth-stage and make you more capable of leading your company through successful scaling and beyond.


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